Focal fits during chlorambucil therapy.

Introduction Chronic lymphatic leukaemia is a disease of the elderly with a long natural history. Treatment is palliative, with chlorambucil the drug of choice (Livingston and Carter, 1970). The recognized side effects of chlorambucil include nausea, myelosuppression, skin eruptions and pulmonary fibrosis (Stenfert Kroese, 1975), but their incidence is low. Although high doses of chlorambucil are epileptogenic in animals (Pradhan and Marsan, 1963) only recently have fits been attributed to chlorambucil therapy, and this in childhood (Williams, Makker and Grupe, 1978). There have been no previous reports of fits in an adult receiving chlorambucil.